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Zapote Mamey YHi Missi! I haven't heard of any long term problems with being on depo provera. The only side effect I've heard of comes from my niece who was on it for about 3 years.
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Sayana® Press: Pilot introduction and evaluation. BACKGROUND Injectable contraceptives are among the world’s most. presentation of Depo-Provera.Changes on contraception: There is no scientific evidence to suggest a link between increase in body weight and long-acting contraceptive intrauterine system.